Mirabegron CAS:223673-61-8 Kaihanga Kaiwhakarato Whakaahua Whakaatu

Mirabegron CAS:223673-61-8 Kaihanga Kaihanga

Ko te Mirabegron mo te maimoatanga o te ohorere, te auau mimi, me te whakakorikori mimi e pa ana ki te toanga o te mimi (OAB).Ka whakahiatotia a Mirabegron ma te hono i te 4-nitrophenethyl amine ki te waikawa (R) -2-hydroxy-2-phenylacetic.Ko te hua o te amide ka heke ki te amine.Ka whakahekehia te roopu nitro ka honoa te hua ki te 2-(2-aminothiazol-4-yl) waikawa acetic hei hoatu mirabegron.

Tono, Tono ranei

Taipitopito Hua

Tohu Hua

Taupānga me te Pānga

Ko te Mirabegron he agonist β3-adrenoceptor a-waha i te wa e whakawhanakehia ana e Astellas Pharma mo te maimoatanga o te pukupuku tino kaha (OAB).Ko te tarukino ko te nanomolar EC50 antagonist ki nga whakamatautau koiora β3-AR tangata me te whiriwhiringa pai mo te b1- me te β2-ARs.E whakaatu ana a Mirabegron i tetahi tikanga hou ma te aro ki te β3-AR mo te whakangā o te tōngāmimi hei awhina i te whakahaere i nga tohu OAB penei i te piki haere o te mimi me te auau me te kore ohorere.Heoi, ko te mirabegron he aukati cytochrome P450 2D6, a ka puta he awangawanga mo te taunekeneke tarukino-taaru me te whakahaere tahi o etahi atu taputapu cytochrome P450 2D6.

Tauira Hua

Tapeke Hua:

Nga korero taapiri:

Te tito	C21H24N4O2S
Te whakamatautau	99%
Te ahua	Ma ki te Koma Kowhai te paura
CAS No.	223673-61-8
Te takai	25KG
Te Ora Papa	2 tau
Rokiroki	Rokiroki ki te waahi makariri me te maroke
Tiwhikete	ISO.