Mirabegron CAS:223673-61-8 Kaihanga Kaiwhakarato

Ko te Mirabegron he rongoā mō te hiahia nui, te auau mimi, me te hiahia nui ki te mimi e pā ana ki te mimi pukumahi rawa (OAB). Ka hangaia te Mirabegron mā te hono i te 4-nitrophenethyl amine ki te waikawa (R)-2-hydroxy-2-phenylacetic. Ka whakaitihia te amide hua hei amine. Kātahi ka whakaitihia te rōpū nitro, ā, ka honoa te hua ki te waikawa acetic 2-(2-aminothiazol-4-yl) hei hanga mirabegron.

Tonohia, Tonoa rānei he Tāpaetanga

Taipitopito Hua

Ngā Tohu Hua

Te Whakamahinga me te Pānga

He agonist β3-adrenoceptor hohe ā-waha a Mirabegron, kei te whakawhanakehia i tēnei wā e Astellas Pharma mō te rongoā i te pūkahukahu kaha rawa (OAB). He rongoā kaiārai nanomolar EC50 tēnei ki ngā whakamātautau matū koiora β3-AR tangata, he pai te whiriwhiri i ngā b1- me β2-AR. E whakaatu ana a Mirabegron i tētahi tikanga hou mā te arotahi ki te β3-AR mō te whakangā o te pūkahukahu hei āwhina i te whakahaere i ngā tohu OAB pērā i te pikinga o te hiahia mimi me te auau me te hiahia kore e taea te mimi. Heoi, he aukati cytochrome P450 2D6 a mirabegron, ā, e ara ake ana he āwangawanga mō te taunekeneke rongoā-rongoā me te whakahaerenga o ētahi atu matū cytochrome P450 2D6 i te wā kotahi.

Tauira Hua

Te Tākai Hua:

Ngā Mōhiotanga Tāpiri:

Te hanganga	C21H24N4O2S
Whakamātautau	99%
Āhua	Paura mā ki te kōwhai mā
Nama CAS	223673-61-8
Te tākai	25KG
Te Ora o te Wāhi	2 tau
Rokiroki	Penapena ki te wāhi hauhautanga, maroke hoki
Tiwhikete	ISO.