Leflunomide CAS:75706-12-6 Kaihanga Kaiwhakarato

Kāore te Leflunomide e mahi, engari ka aukati te teriflunomide i te hanga pyrimidine de novo i ngā horopeta rongoā iti mā te aukati i te dihydroorotate dehydrogenase (te whākōkī whakatau tere mō te hanga o te UMP), te whakaiti i te hanga DNA me te RNA, me te aukati i te huringa tipu pūtau me te hanga o ngā paturopi. Ka puta te whakahekenga o te dihydroorotate ki te orotate i te wā kotahi me te whakahekenga o tana cofactor, ubiquinone (coenzyme Q). Ko te aukati i te dihydroorotate dehydrogenase e te teriflunomide e whakaatu ana i te kaha kore whakataetae me te kore whakataetae. Ko te whakahaerenga o te leflunomide ki ngā tūroro e pangia ana e te mate rumatiki ka hua ake te tango haere i ngā pūtau B me te whakahekenga o te tukanga ārai mate.