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Lasmiditant CAS:439239-90-4
Ko te Lasmiditan, e hokohokohia ana i raro i te ingoa waitohu Reyvow, he matū rongoā hou i hangaia hei whakamamae i ngā whakaekenga migraine tere i roto i ngā pakeke. Nō roto i te akomanga o ngā agonists receptor serotonin whiriwhiri, e aro ana ki te momo receptor 5-HT1F. Mā tēnei tikanga mahi ka wehewehe a Lasmiditan i ngā maimoatanga migraine tuku iho, nā te mea kāore e puta he vasoconstriction, he mea pai mō ngā tūroro he take mōrearea cardiovascular.
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N-Methylcarbonyl-2-chloroacetamidrazone CAS:155742-64-6
He matū te N-Methylcarbonyl-2-chloroacetamidrazone e mōhiotia ana mō ōna whakamahinga maha i roto i te hanganga rauropi me te matū taunga. Ko tōna hanganga ko te tauhohenga o te N-methylcarbamoyl chloride me te 2-chloroacetohydrazide, ka hua ake he matū he āhuatanga hanganga me te mahi motuhake. Ko te āhuatanga o tēnei matū ko tōna kaha ki te hanga matatini me ngā momo katote konganuku, e whai hua ai i roto i ngā rangahau matū taunga. Hei tāpiri, ko ōna rōpū carbonyl me amidrazone e whai wāhi ana ki tōna tauhohenga me ngā mahi rongoā pea, he wāhanga rangahau tonu ēnei e pārekareka ana.
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Lasmiditan HCl CAS:613677-28-4
Ko te Lasmiditan hydrochloride (Lasmiditan HCl) he matū rongoā e mōhiotia ana mō tana mahi ki te rongoā i ngā whakaekenga migraine tere i roto i ngā pakeke. I whakawhanakehia hei kaiwhakawhiwhi serotonin whiriwhiri, e aro ana ki te momo kaiwhakawhiwhi 5-HT1F, ko te Lasmiditan HCl he whanaketanga nui i roto i te rongoā migraine nā tōna tikanga mahi ahurei me tōna whai huatanga haumanu.
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(6-aMinopyridin-2-yl)(1-Methylpiperidin-4-yl)Methanone CAS:613678-03-8
Ko te (6-Aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone, e mōhiotia ana ko te aminopyridine methylpiperidone, he matū e whai pānga nui ana ki te matū rongoā me te rangahau rongoā. I hangaia mā te tauhohenga o te waikawa 6-aminopicolinic me te 1-methylpiperidin-4-one, e whakaatu ana tēnei matū i ngā āhuatanga hanganga motuhake e whai wāhi ana ki tōna pūmanawa rongoā me tōna whānuitanga mahi.
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(S)-(+)-3-Quinuclidinol CAS:34583-34-1
Ko te (S)-(+)-3-Quinuclidinol, e mōhiotia whānuitia ana ko te quinuclidinol, he matū nui i roto i te matū waro me te rangahau rongoā nā tōna hanganga ahurei me ōna whakamahinga maha. I ahu mai tēnei matū chiral i te quinuclidine, ā, he rerekē ōna āhuatanga matū me te rongoā kua arohia puta noa i ngā momo marautanga pūtaiao.
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NGĀ WAENGA TAKAWATE APREPITANT CAS:171482-05-6
He mahi nui tā ngā takawaenga aprepitant i roto i te hanganga rongoā o te aprepitant, he kaitukino neurokinin-1 (NK1) kaha e whakamahia ana i te nuinga o te wā hei ārai i te whakapairuaki me te ruaki i puta mai i te chemotherapy (CINV). He wāhanga nui ēnei takawaenga i roto i te ara hanga maha-taahiraa e arahi ana ki te hanganga whakamutunga o te aprepitant. E mōhiotia ana te aprepitant mō tōna whai huatanga ki te whakahaere i te CINV, e tuku ana i te whakaora nui ki ngā tūroro e pangia ana e te chemotherapy. He maha ngā taahiraa matua o te hanganga o te aprepitant, me ngā takawaenga e mahi ana hei poraka hanga e āhei ai te whakaputa pai o tēnei kaihoko whakaora nui.
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2,4,6-TRIFLUOROBENZOYL HĀRĀWAI CAS:79538-29-7
Ko te 2,4,6-Trifluorobenzoyl chloride, e mōhiotia ana ko te trifluorobenzoyl chloride, he matū matua e whai hua ana mō ōna whakamahinga maha i roto i te hanga matū waro me ngā tukanga ahumahi. I hangaia mā te whakakōroi i te waikawa 2,4,6-trifluorobenzoic, ka whakaatuhia e tēnei matū ngā āhuatanga matū motuhake e whai wāhi ana ki tōna whakamahinga whānui puta noa i ngā mara rerekē.
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4-Chloro-6-iodoquinazoline CAS:98556-31-1
He matū te 4-Chloro-6-iodoquinazoline, ko tōna tātai ngota C9H5ClIN2. Ko tōna āhua he kitea i te aroaro o ngā ngota chlorine me te iodine e piri ana ki te hanganga mowhiti quinazoline. E whakamahia nuitia ana tēnei matū i roto i ngā rangahau rongoā me te hanga rauropi nā te mea he maha ngā whakamahinga pea mō te whakawhanake i ngā rongoā hou me ētahi atu ngota koiora kaha.
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(R)-3-Quinuclinol CAS:25333-42-0
Ko te (R)-3-Quinuclinol, e mōhiotia ana ko te quinuclidinol, he matū nui i roto i te matū waro me te rangahau rongoā nā tōna hanganga ahurei me ōna whakamahinga maha. I ahu mai tēnei matū chiral i te quinuclidine, ā, he rerekē ōna āhuatanga matū me te rongoā kua arohia puta noa i ngā momo marautanga pūtaiao.
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![(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate CAS:200000-59-5](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT235.png)
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate CAS:200000-59-5
Ko te matū (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate he ngota waro matatini me ngā āhuatanga hanganga me ngā āhuatanga rongoā motuhake. Nō te akomanga morpholine o ngā matū, e whakamahia ana i roto i te matū rongoā nā te maha o ā rātou mahi koiora.
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![(S)-3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzenemethanamine CAS:608141-42-0](https://cdn.globalso.com/xindaobiotech/1ZNB2ZF342ZWRNG304.png)
(S)-3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzenemethanamine CAS:608141-42-0
He matū te (S)-3-Ethoxy-4-methoxy-α-[(methylsulfonyl)methyl]benzenemethanamine e mōhiotia ana mō ōna whakamahinga maha i roto i te hanga rauropi me te matū rongoā. I hangaia mā te tauhohenga o te (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanone me te haukini, te amine rānei, he āhuatanga hanganga motuhake tēnei e whai wāhi ana ki tōna kanorau mahi me ngā mahi rongoā pea.
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(R)-1-(3-Ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethylaMine CAS:608142-27-4
Ko te (R)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamine he matū e mōhiotia ana mō ōna whakamahinga kanorau i roto i te hanga rauropi me te matū rongoā. I hangaia mā te tauhohenga o te 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanone me te haukini, te amine rānei, e whakaatu ana tēnei matū i ngā āhuatanga hanganga motuhake e whai wāhi ana ki tōna whānuitanga mahi me ngā mahi rongoā pea.
