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Adenosine CAS:58-61-7
Ko te Adenosine he nucleoside i titoa mai i te adenine me te ribose, he mahi nui tana i roto i te pākia o te pūtau. He poraka hanga taketake tēnei mō te adenosine triphosphate (ATP), te moni pūngao matua i roto i ngā pūnaha koiora. Haunga ōna mahi e pā ana ki te pūngao, kei roto te adenosine i ngā tukanga ā-tinana maha, tae atu ki te tuku i te neurotransmission, te whakanui i te vasodilation, me te whakahaere i te huringa moe-ara. Ka mahi ia ki ngā kaiwhakawhiwhi motuhake, ka awe i te tere o te ngakau me te rere o te toto. I roto i te haumanu, ka whakamahia te adenosine i roto i te rongoā, inā koa i roto i te rongoā i ētahi arrhythmias ngakau. Ko ōna mahi maha-taha e whakaatu ana i te hiranga o te adenosine ki te hauora me te mate.
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Uridine 5-monophosphate, tote disodium CAS:3387-36-8
Ko te Uridine 5-monophosphate, disodium salt (UMP) he nucleotide e whai wāhi nui ana ki te pākia o te pūtau me te hanga RNA. Kei roto ko te pyrimidine base uracil, he huka ribose, me te rōpū phosphate, he mea nui te UMP mō ngā tukanga koiora maha, tae atu ki te hanganga o ngā waikawa nucleic me te whakahaere i ngā ara pākia. Ka whakarei ake te ahua tote disodium i tōna wairewatanga me te pumau i roto i ngā otinga wai, e pai ai mō ngā rangahau taiwhanga me ngā tono rongoā. Kua arohia te UMP mō ōna āhuatanga tiaki io me te whakarei ake i te hinengaro, me tana mahi ki te whakatairanga i te hauora pūtau whānui.
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Cytidine 5′-(disodium phosphate) CAS:6757-06-8
Ko te Cytidine 5′-(disodium phosphate) he matū ira-pūmua i hangaia mai i te cytosine pūtake pyrimidine, te huka ribose, me te rōpū phosphate. He mahi nui tā tēnei matū i roto i ngā tukanga matū koiora maha, tae atu ki te hanganga RNA, ngā ara whakahaere, me te tohu pūtau. Ka whakarei ake te āhua tote disodium i tōna wairewatanga me te pumau i roto i ngā āhuatanga ā-tinana, ā, he pai mō te rangahau taiwhanga me ngā tono rongoā pea. Kua piki ake te hiahia mō te Cytidine 5′-(disodium phosphate) mō tōna whai wāhi ki te pākia o te waikawa karihi me ōna painga pea ki te whakarei ake i te mahi hinengaro me te tautoko i te hauora pūtau.
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5-Azacytidine CAS:320-67-2
Ko te 5-Azacytidine he rite ki te nucleoside hangai o te cytidine kei roto he ngota hauota i te tūranga-5 o te mowhiti pyrimidine, hei whakakapi i te ngota waro. Mā tēnei whakarerekētanga ka puta he āhuatanga rongoā ahurei, ka waiho hei matū nui i roto i te koiora ngota me te rongoā mate pukupuku. Hei aukati kaha i te DNA methyltransferase, ka taea e te 5-azacytidine te whakahohe anō i ngā ira kua whakawāteatia mā te whakarerekē i ngā tauira methylation DNA, ā, ka awe i te whakaaturanga ira. I whakawhanakehia tuatahitia hei rongoā i ngā mate pukupuku toto, kua arohia te 5-azacytidine mō ōna tono pea i roto i te rongoā epigenetic, te rongoā whakaora, me te rangahau e aro ana ki ngā mate maha e tohuhia ana e te whakahaere ira rerekē.
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2′-Fluoro-2′-deoxyuridine CAS:784-71-4
Ko te 2′-Fluoro-2′-deoxyuridine (FdU) he rite ki te nucleoside o te deoxyuridine, ka whakakapia te ngota hauwai i te tūranga 2′ o te huka ribose e te ngota fluorine. Ka whakarei ake tēnei whakarerekētanga i te pumau me te mahi koiora o te matū, ka whai hua ai i roto i ngā rangahau matū koiora me ngā tono rongoā. E mōhiotia whānuitia ana a FdU mō tana mahi hei kaihoko ārai huaketo me te ārai matepukupuku, nā te mea ka taea e ia te whakararuraru i te hanganga DNA me te aukati i te whakaputa uri o ētahi huaketo me ngā pūtau matepukupuku. Nā ōna āhuatanga ahurei ka waiho hei taputapu nui i roto i te whakawhanaketanga o ngā maimoatanga kua tohua me ngā rangahau koiora ngota.
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![4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1](https://cdn.globalso.com/xindaobiotech/8NS8DBIRAVXN0VCLT260.png)
4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one CAS:10212-20-1
Ko te 4-Amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one he rite ki te nucleoside matatini e whakaatu ana i te turanga pyrimidine e piri ana ki te huka ribose kua whakarerekētia. Ko te aroaro o te ngota fluorine me ngā rōpū hydroxyl i roto i tōna hanganga ka whakarei ake i ōna āhuatanga matū koiora, ka waiho hei kaitono whakamere mō te rangahau ārai huaketo me te ārai matepukupuku. He pea ngā tono o tēnei matū i roto i te matū rongoā, inā koa hei kaihoko rongoā e aro ana ki te hanganga waikawa nucleic me ngā ara metabolic i roto i ngā rauropi pathogenic. Ko ōna āhuatanga hanganga ahurei ka taea te taunekeneke pai ake me ngā whāinga koiora e uru ana ki te metabolism DNA me te RNA.
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1,3,5-tri-O-benzoyl-alpha-D-ribofuranose CAS:22224-41-5
Ko te 1,3,5-Tri-O-benzoyl-alpha-D-ribofuranose he momo ribose kua whakarerekētia te matū, e whakaatu ana i ngā rōpū benzoyloxy e toru e piri ana ki ngā tūranga 1, 3, me te 5 o te hanganga ribofuranose. Mā tēnei whakarerekētanga ka whakarei ake i tōna wairewatanga me tōna pumau, ka whai hua ai i roto i ngā tono hangai i roto i te matū waro me te matū koiora. Hei matū tiaki o te ribose, ka mahi hei takawaenga i roto i te hanga o ngā nucleosides me ngā nucleotides, ngā wāhanga nui o te RNA me te DNA. Nā ōna āhuatanga ahurei ka whai hua te 1,3,5-tri-O-benzoyl-alpha-D-ribofuranose mō ngā kairangahau e rapu ana ki te whakawhanake i ngā kaihoko rongoā hou me ngā rauemi i roto i te matū nucleotide.
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2′-O-methyluridine CAS:2140-76-3
Ko te 2′-O-Methyluridine he nucleoside tūturu e piri ana te rōpū methyl ki te ngota hāora o te tūranga 2′ o te huka ribose i roto i te uridine. Mā tēnei whakarerekētanga ka whakarei ake i te pumau me te mahi a ngā ngota RNA, ka waiho hei wāhanga nui i roto i ngā tukanga koiora. He mahi nui tā te 2′-O-Methyluridine i roto i te hanganga me te mahi a ngā waikawa ribonucleic (RNA), tae atu ki te RNA karere (mRNA) me te RNA whakawhiti (tRNA). Ka taea e tōna aroaro te awe i te pumau o te RNA, te pai o te whakamaoritanga, me ngā taunekeneke ki ngā pūmua me ētahi atu waikawa nucleic, ka waiho hei wāhanga nui i roto i te ako i te koiora ngota me ngā tono rongoā.
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adenosine 5′-monophosphate konutai*mai i te rewena CAS:4578-31-8
Ko te Adenosine 5′-monophosphate sodium (AMP) he nucleotide i ahu mai i te adenosine e whai wāhi nui ana ki te pākia o te pūtau. He mea nui te AMP mō ngā tukanga koiora maha, tae atu ki te whakawhiti pūngao, te whakawhiti tohu, me te mea hei matū mō te hanganga o te ATP me ētahi atu nucleotide. Ka taea te ahu mai i te rewena te tote konutai o te AMP, he nui ngā nucleotide nā ōna ara pākia kaha. He mea whakamahi noa tēnei matū i roto i te matū koiora me te rongoā hei matū matū koiora, hei tāpiri kai, hei tāpiringa kai, nā te mea he pai pea ki te hauora me ngā tono hei whakatairanga i te pākia o te pūngao.
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2′-Deoxycytidine CAS:951-77-9
Ko te 2′-Deoxycytidine he nucleoside i titoa mai i te huka deoxyribose me te cytosine, e wehewehea ana e te korenga o te rōpū hydroxyl i te tūranga 2′ o te ribose. Nā tēnei whakarerekētanga ka waiho hei wāhanga nui o te DNA, ka honoa ki te guanine i te wā e honoa ana te turanga. He mahi nui tā te 2′-Deoxycytidine i roto i te pākia o te pūtau me te hanga DNA, hei poraka hanga mō te deoxycytidine triphosphate (dCTP), he mea nui mō te tāruarua me te whakatikatika DNA. Hei tāpiri, he pānga nui tō tēnei nucleoside ki te rangahau koiora ngota, te rongoā mate pukupuku, me ngā rautaki ārai huaketo, e whakaatu ana i tōna hiranga ki ngā rangahau taketake me ngā tono haumanu.
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2,2′-cyclouridine CAS:3736-77-4
Ko te 2,2′-Cyclouridine he pūhui nucleoside bicyclic o te uridine, e tohuhia ana e te hanganga o tētahi hanganga huringa ahurei e uru ana ki ngā tūranga 2′ me 2” o te wāhanga ribose. Mā tēnei whakarerekētanga hanganga ka puta he āhuatanga matū koiora motuhake e awe ana i tōna pumau me te mahi koiora. Kua piki ake te hiahia o te 2,2′-Cyclouridine ki te koiora matū me te matū rongoā nā te mea ka taea te whakamahi hei kaihoko ārai huaketo me te rangahau RNA. Nā tōna kaha ki te whakarerekē i ngā taunekeneke waikawa nucleic ka waiho hei taputapu whai hua mō te ako i ngā whanaungatanga hanganga-mahi RNA, ka arahi pea ki ngā whanaketanga i roto i ngā rautaki rongoā e aro ana ki ngā mate huaketo me ngā mate ira.
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2-Aminoadenosine CAS:2096-10-8
Ko te 2-Aminadenosine he matū nucleoside tūturu o te adenosine, e kitea ana i te aroaro o tētahi rōpū amino i te tūranga-2 o te huka ribose. Ka tino whakarerekētia e tēnei whakarerekētanga ōna āhuatanga matū koiora me āna mahi, ka waiho hei ngota matū nui i roto i ngā tukanga tinana. Kei roto te 2-Aminadenosine i roto i te tohu pūtau, te pākia o te tinana, me ngā ara whakahaere, tae atu ki ngā mea e pā ana ki te homeostasis pūngao me te tuku neurotransmission. Ko ōna tono rongoā pea e horapa ana i ngā mara maha, tae atu ki te neurobiology me te cardiology, ka pā pea ki ngā urupare pūtau ki te ahotea me te whara. I te haere tonu o ngā rangahau, he pai te 2-aminoadenosine mō te whakawhanake i ngā matū koiora hou me ngā kaihoko rongoā.
