β-Nicotinamide Mononucleotide CAS:1094-61-7

Ko te β-Nicotinamide mononucleotide (NMN) e whakamahia ana ki te ako i nga kaupapa here i roto i nga aptamers RNA me nga tukanga whakahohe ribozyme e uru ana ki nga wahanga RNA β-nicotinamide mononucleotide (β-NMN) -whakahohe.Ko te NMN he nucleotide i ahu mai i te ribose me te nicotinamide.Ko te Niacinamide (nicotinamide,) he huaora o te huaora B3, e mohiotia ana ko te niacin.) Hei tohu matū koiora o NAD +, ka whai hua pea ki te aukati i te pellagra.
Ko te β-Nicotinamide mononucleotide he takawaenga i roto i te koiora o te nicotinamide adenine dinucleotide (NAD+).Ko te Nicotinamide phosphoribosyltransferase (Nampt) ka whakakorikori i te condensation o te nicotinamide me te 5-phosphoribosyl-1-pyrophosphate ki te whakaputa i te β-NMN, ka huri i muri mai ki te NAD + e te β-NMN adenyltransferase. I te 50-100 μM, kua whakamahia te β-NMN NAD biosynthesis me te hukahuka-whakaongaonga insulin secretion i roto i te Nampt +/- tauira kiore o te mate metabolic, e whakaatu ana i te mahi mo Nampt i roto i te mahi pūtau β.