Tofacitinib CAS:477600-75-2 Kaihanga Kaiwhakarato

He rongoā a Tofacitinib mō te rongoā i te mate rumatiki (RA), te psoriasis, te mate puku mumura, me ētahi atu mate ārai mate, tae atu ki te ārai i te whakakorenga o te whakawhitinga okana. He aukati i te whākōkī Janus kinase 3 (JAK3), ko te tikanga ka whakararuraru i te ara tohu JAK-STAT e tuku ana i ngā mōhiohio ki waho o te pūtau ki roto i te pūtake pūtau, ka awe i te tuhi DNA. Nō nā tata nei kua whakaaturia i roto i tētahi tauira kiore o te mate rumatiki kua whakapumautia, ka tere te whakapai ake a tofacitinib i te mate mā te aukati i te hanga o ngā takawaenga mumura me te pehi i ngā ira e whakawhirinaki ana ki te STAT1 i roto i te kiko hononga. Ko tēnei whai huatanga i roto i tēnei tauira mate e hono ana ki te aukati i ngā ara tohu JAK1 me te 3, e kī ana ka whai hua pea a tofacitinib mā roto i ngā ara kāore i te aukati i te JAK3 anake.