β-Nicotinamide Mononucleotide CAS:1094-61-7

Ko te Nicotinamide mononucleotide (NMN), he hua o te tauhohenga NAMPT me te takawaenga matua o te NAD+, ka whakapai ake i te kore manawanui ki te huka mā te whakaora i ngā taumata NAD+ i roto i ngā kiore T2D i puta mai i te HFD. Ka whakarei ake hoki te NMN i te aro o te ate ki te insulin me te whakaora i te whakaaturanga ira e pā ana ki te ahotea waikura, te urupare mumura, me te manawataki circadian, mā te whakahohenga SIRT1. Ka whakamahia te NMN mō te ako i ngā kaupapa here i roto i ngā RNA aptamers me ngā tukanga whakahohenga ribozyme e uru ana ki ngā kongakonga RNA i whakahohehia e te β-nicotinamide mononucleotide (β-NMN).

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Te Whakamahinga me te Pānga

Ka whakamahia te β-Nicotinamide mononucleotide (NMN) hei ako i ngā tohu here i roto i ngā RNA aptamers me ngā tukanga whakahohe ribozyme e uru ana ki ngā kongakonga RNA whakahohe-β-nicotinamide mononucleotide (β-NMN). Ko te NMN he nucleotide i ahu mai i te ribose me te nicotinamide. Ko te Niacinamide (nicotinamide,) he pūtake o te huaora B3, e mōhiotia ana ko te niacin.) Hei matū matū mua o te NAD+, tera pea he whai hua ki te aukati i te pellagra.
Ko te β-Nicotinamide mononucleotide he takawaenga i roto i te hanganga o te nicotinamide adenine dinucleotide (NAD+). Ka whakakorikori te Nicotinamide phosphoribosyltransferase (Nampt) i te whakakotahitanga o te nicotinamide me te 5-phosphoribosyl-1-pyrophosphate hei whakaputa i te β-NMN, ka hurihia hei NAD+ mā te β-NMN adenyltransferase. I te 50-100 μM, kua whakamahia te β-NMN hei whakarei ake i te hanganga NAD me te whakaputanga insulin i whakaohohia e te huka i roto i te tauira kiore Nampt+/- o te mate pākia, e whakaatu ana i te mahi a Nampt i roto i te mahi pūtau β.

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Ngā Mōhiotanga Tāpiri:

Te hanganga	C11H15N2O8P
Whakamātautau	99%
Āhua	Paura mā
Nama CAS	1094-61-7
Te tākai	25KG
Te Ora o te Wāhi	2 tau
Rokiroki	Penapena ki te wāhi hauhautanga, maroke hoki
Tiwhikete	ISO.