VALINOMYCIN CAS:2001-95-8 Utu a te Kaihanga

Ko te mahi matua a te Valinomycin he ionophore, arā, ka āwhina i te kawe i ngā katote motuhake puta noa i ngā kiriuhi pūtau. Ko tōna pānga tino kitea ko tōna kaha ki te hono atu ki ngā katote pāhare pāporo (K+). Ka hangaia e te Valinomycin he matatini ki ngā katote K+, ā, he tino whiriwhiri mō te kawe i a rātou.

Ko tētahi o ngā whakamahinga matua o te valinomycin he ionophore i roto i ngā irahiko whiriwhiri-katote hei ine i ngā kukū pāhare pākawa i roto i ngā tauira koiora. Ka whakamahia e ēnei irahiko te kaha o te valinomycin ki te here me te kawe i ngā irahiko K+, ka taea ai te ine tika me te tairongo i ngā irahiko pāhare pākawa.

Nā te kaha o Valinomycin ki te kawe i ngā katote pāhare pāporo, he mea nui hoki tēnei i roto i ngā rangahau e pā ana ki te kawe katote me te pūmanawa kiriuhi i roto i ngā pūtau. E whakamahia ana hei ako i te mahi a ngā hongere katote, te pūmanawa kiriuhi, me ngā pikinga katote i roto i ngā tukanga koiora.

Heoi anō, kua rangahaua te valinomycin mō ōna whakamahinga rongoā pea. Kua whakaatuhia he hua whai hua hei ārai matepukupuku i roto i ētahi momo matepukupuku. Ka puta te apoptosis (mate pūtau) i roto i ngā pūtau matepukupuku mā te whakararuraru i tō rātou kaha membrane mitochondrial.