Nigericin CAS:28380-24-7

Kua whānuitia te whakamahinga o te Nigericin i roto i ngā taiwhanga rangahau hei ako i ngā tikanga kawe katote pūtau, te whakahaere pūmanawa membrane, me te whakarerekētanga pH intracellular. Nā ōna āhuatanga ionophoric he taputapu whai hua mō te tirotiro i ngā ara tohu katote, te urunga membrane, me te homeostasis pūtau. He maha ngā wā ka whakamahia e ngā kairangahau te nigericin hei whakahaere i ngā kukū katote i roto i ngā pūtau me te tūhura i ōna pānga ki te mahi me te oranga o te pūtau. Haunga āna tono rangahau, kua whakaatuhia e te nigericin ngā āhuatanga ārai matepukupuku whai hua mā te whakaoho i te apoptosis (te mate pūtau kua whakaritea) i roto i ngā pūtau matepukupuku. Kua whakaatuhia e ngā rangahau te kaha o te nigericin ki te aukati i te tipu o ngā pūtau matepukupuku, te whakaoho i te ngoikore o te mitochondrial, me te whakararuraru i ngā ara tohu oncogenic. E whakaatu ana ēnei kitenga i te whakamahinga pea o te nigericin hei rongoā mō ētahi momo matepukupuku, e whakaatu ana i tana mahi i roto i te rangahau matepukupuku me te whakawhanaketanga rongoā. Ahakoa he whai hua te nigericin i roto i ngā rangahau pūtaiao me te rangahau matepukupuku, ko tōna kaha koiora me whakahaere me te whakamahi whakahaere i roto i ngā tautuhinga taiwhanga. Me piri ngā kairangahau e mahi ana me te nigericin ki ngā aratohu haumaru me ngā tikanga hei whakarite i te pupuri me te whakakorenga tika. He mea nui te mahi tahi me ngā tohunga mohio, me te whai i ngā tikanga kua whakapumautia ina whakamahia ana te nigericin mō ngā kaupapa rangahau, ina tūhuratia rānei tōna pūmanawa rongoā i roto i ngā tono hauora maha.