Te rangahau hou mō te Huaora K2 MK7

Ko te Huaora K2 MK7 (Menaquinone-7) he momo Huaora K2 tino whaihua, he momo koiora hoki, e tino arohia ana mō ōna mahi nui ki te hauora o te ngākau me te wheua. Anei tētahi whakamārama taipitopito.

· Tuakiri Matū: Ko te Huaora K2 he wāhanga o te whānau menaquinone (MK), e tohuhia ana e te mekameka taha o ngā waeine prenyl e tāruarua ana. Kei roto i te MK7 e whitu o ēnei waeine isoprenoid ("MK" te tikanga mō Menaquinone, ko te "7" te tohu i te roa o te mekameka).

· Ngā Pūtake Taiao:

· Ngā Kai Whakarewa: Ko te puna kai tino momona ko te natto (he kai tuku iho a Hapanihi i hangaia mai i te pīni soya whakarewa). Ko ētahi atu kai whakarewa pērā i ētahi tiihi (hei tauira, Gouda, Brie) me te sauerkraut he iti ake, he rerekē hoki ngā rahinga.

· Ngā Pūtake Kararehe: He iti noa te nui o te kitea i roto i ngā toene hua manu, te ate, me ngā mīti momona mai i ngā kararehe e whāngai ana i te tarutaru.

· Ngā Tāpiringa: He whānuitia te wātea hei tāpiringa kai, he maha ngā wā ka ahu mai i te whakapūtanga natto, ka hangaia rānei mā te hangarau. He maha ngā wā ka honoa ki te Huaora D3 me te konupūmā hei whakatutuki i ngā pānga mahi tahi.

Koinei te ariā matua e wehewehe ana i te Huaora K2 (ina koa ko te MK7):

· Whakahohe i te Matrix Gla Protein (MGP): He kaha te aukati a te MGP i te whakapūngao o ngā oko toto. Ka herea ki ngā iona konupūmā i roto i ngā pakitara o ngā oko toto, ā, ka ārai i a rātou kei putunga ki roto i ngā kiko ngohengohe (ngā uaua, ngā whatukuhu). Ka whakahohe a MK7 i te MGP. Ki te kore e ranea te K2, ka noho kore mahi te MGP, ka piki ake te mōrearea o te whakapakeketanga o ngā oko toto me te mate ngakau.

· Whakahohe i te Osteocalcin: He pūmua te Osteocalcin i hangaia e ngā osteoblast (ngā pūtau hanga wheua). Ko tana mahi he here i te konupūmā me te whakauru ki roto i te anga wheua, hei whakapakari i te wheua. Ka whakahohe a MK7 i te osteocalcin.

· He kupu whakarite mō te "Kaiwhakahaere Konupūmā": Whakaarohia te Huaora D hei "kaitiaki kūaha" e whakarite ana kia mimitihia te konupūmā mai i te puku ki roto i te toto. Ko te Huaora K2 (MK7) te "kaiwhakahaere waka" te "kawe waka", e whakarite ana kia whakatakotoria te konupūmā ki roto i ngā wheua (mā te osteocalcin) me te pupuri kia kore e uru ki ngā uaua toto (mā te MGP).

1. Hauora o te Ngākau:

· Whakaiti i te Pakaritanga o te Uaua me te Whakapūngā: He maha ngā rangahau tirotiro me ngā rangahau wawaotanga e hono ana i te nui ake o te kai K2 (MK7) me te whakaiti i te mōrearea o te mate ngakau, te whakapūngā o ngā uaua, me te mate. He rangahau rongonui te Rangahau ROTTERDAM e whakaatu ana i tēnei painga.

· Whakapai Ake i te Ngāwari: Kua whakaatuhia te whakapai ake i te ngāwari o ngā uaua mā te tāpiringa kai (hei tauira, 180-360 µg/rā mō ētahi tau).

2. Hauora o te Wheua:

· Whakaiti i te Mōrearea o te Whati: Ina koa ko ngā wāhine kua mutu te pāheketanga. Ka mahi tahi a K2 me te Huaora D me te konupūmā hei whakapai ake i te kiato o te wheua (BMD) me te whakaiti i te maha o ngā whati (tuara me te hope).

· Ārai i te Osteoporosis: Mā te whakahohe katoa i te osteocalcin, ka tautoko i te tukanga whakahou wheua, ka pai ake te hanganga wheua i te mimiti.

3. Ētahi atu Whakamahinga Pea (Rangahau Hou):

· Te Tairongo ki te Insulin me te Mate Huka: Tērā pea ka whai wāhi te Osteocalcin, ina whakahohehia e te K2, ki te whakapai ake i te tairongo ki te insulin.

· Hauora o te Whatukuhu: Tērā pea ka āwhina i te aukati i te whakapūngā o ngā oko toto i roto i ngā tūroro e pāngia ana e te mate whatukuhu mau tonu (CKD), ahakoa me tirotirohia e te rata te whakamahinga i roto i te CKD nā te mea ka pā mai ngā raruraru pea.

· Hauora Niho: He rite ki te wheua, ka tautoko pea i te whakapūngatanga o ngā niho mā te osteocalcin.

· Hauora Hinengaro: E hono ana ētahi rangahau tuatahi i te hauora o ngā oko toto (e tautokona ana e K2) me te whakaiti i te mōrearea o te hekenga o te hinengaro.

Huaora Huaora K2 MK7 Huaora K2 MK4

Pūtake I ahu mai i te whakapūtanga huakita (natto). Kei roto i ngā hua kararehe; he mea hangai te nuinga o ngā tāpiringa.

Te haurua-ora Te roa (~72 hāora). Ka whakarato i ngā taumata toto pumau, pumau mai i te horopeta kotahi. He poto (~1-2 hāora). Me whakamahi pinepine (he maha ngā wā i te rā).

Te Wātea Mai o te Koiora Tino Pai; ko tōna roa o te haurua-ora ka hua ake he taumata toto teitei ake, he pumau ake hoki. Ko te pai o te whakakorenga engari he tere te whakakorenga ka whakawhāiti i te kohikohinga kiko.

Ko te horopeta noa ko te 90-360 µg/rā te mea noa mō te tāpiringa. He maha ngā wā ka whakamahia i roto i ngā horopeta rongoā (1.5-45 mg/rā) i roto i ngā rangahau haumanu.

Whakamahinga Matua Hauora ārai roa mō ngā wheua me ngā uaua (tāpiritanga kai). Rongoā whakahaunga (i Hapani) mō te osteoporosis me te ngaronga wheua i puta mai i te steroid.

Ngā Taunakitanga He kaha ngā raraunga whakamātautau haumanu mō ngā painga o te mate urutā me te tipu haere mō ngā painga o te ngākau me te ngākau. He kaha ngā raraunga whakamātautau haumanu mō ngā painga o te wheua i ngā horopeta teitei, rongoā.

Whakatau: Ko te MK7 te mea e pai ake ana mō te tāpiringa o ia rā nā te mea he pai ake ōna āhuatanga pharmacokinetic (he roa te haurua-ora), e āhei ai te horopeta kotahi i te rā me te whakahohenga tonu o ngā pūmua e whakawhirinaki ana ki te K.

· Te Horomanga Tāpiri Noa: Kei waenga i te 90 maikirokaramu (µg) ki te 360 ​​µg ia rā. Ko te nuinga o ngā rangahau mō ngā painga o te ngakau me te ngākau e whakamahi ana i te 180-200 µg/rā.

· Haumaru: Tino haumaru i ngā horopeta kua tūtohutia mō te marea whānui. Kāore anō kia whakatūria he taumata paitini e mōhiotia ana.

· Te Taunekeneke Hira – Ngā Rongoā Whakaheke Toto (Warfarin/Coumadin):

· Ka ārai te Huaora K i te pānga o te Warfarin. Me pupuri tonu e ngā tūroro e tango ana i te Warfarin te nui o te Huaora K (mai i te kai me ngā tāpiringa) kia mau tonu ai te horopeta o te rongoā.

· Kaua e tīmata, e whakamutu rānei i ngā tāpiringa K2 me te kore he tirotiro tata a te rata me te aroturuki auau i te INR. Kāore ngā rongoā anticoagulant hou (ngā DOAC pēnei i te apixaban, rivaroxaban) e taunekeneke me te Huaora K.

· Ngā Mahi Tahi: Me kai tahi me te Huaora D3. He takirua kaha e mahi tahi ana. He mea nui anō hoki te konupūmā me te konupora hei matūkai tahi.

· Āhua: He pai rawa ngā kapene ngohengohe, ngā kāpū rānei he hinu kei roto (hei tauira, te hinu oriwa, te hinu MCT), nā te mea he wairewa te Huaora K2 i te ngako.

· Ngā Tātai Whakakotahi: Rapua ngā hua e whakakotahi ana i te K2 (MK7) me te D3. He pai hoki te tāpiri i te iti o te Huaora K1 mō te tūnga K whānui.

· Kounga: Kōwhiria ngā waitohu e whakamahi ana i te MK7 whakawhiti-katoa (te momo koiora; kei roto pea i ētahi hua hangai te isomer cis iti ake te kaha).

· Te Rokiroki: Puritia ki te wāhi hauhautanga, pōuri. Ka pumau i roto i ngā tāpiringa mena ka tiakina mai i te mārama me te wera.

Hei whakarāpopototanga, he matūkai nui te Huaora K2 MK7 e tuku ana i te konupūmā ki te angaanga, me te tiaki hoki i ngā uaua me ngā kiko ngohengohe mai i te whakapūngā. Nā te roa o te haurua o te ora me te kaha o ngā taunakitanga, he mea nui tēnei hei wāhanga o tētahi tikanga hauora ārai mate, inā koa mō te hauora o te ngākau me te wheua, ina whakamahia ngātahi me te Huaora D3.