Ko te matū Neocuproine he matū hei whakatau i te parahi, he karaihe mā, he kōwhai-parauri rānei, he mea whakapataritari. E whakamahia ana hei matū hei whakatau i te parahi kapurou, te whakatau i te parahi whakaahua, te whakatau i te huka toto tino-iti; te hanga rauropi. Kua whakamahia te Neocuproine hydrochloride monohydrate ki te ine i te whakarewatanga parahi i roto i ngā koranu Cu–Ni mā te whakamahi i te tikanga tae. Kua whakamahia hoki ki te whakarite i te otinga matū whakahiato i roto i te ako i ngā whakamātautau kaha antioxidant i roto i ngā tauira koiora i runga i ngā matū whakaiti Cu. Ka taea te whakamahi hei matū mua mō te whakarite i te neocuproine, ka whakamahia hei matū tātari mō te whakatau i te parahi i roto i ngā tauira taiao mā te whakamahi i te tikanga spectrophotometric.
Heoi, he rerekē rawa ngā whakamahinga o taua rongoā i roto i te rongoā. Nō nā tata nei, kua whakaaetia a Eribulin kia hokohokohia e te National Medical Products Administration (NMPA) o tōku whenua hei rongoā i ngā tūroro mate pukupuku ū e hokihoki mai ana, e horapa ana rānei i te rohe, kua whiwhi i te iti rawa i te rua ngā rongoā chemotherapy (tae atu ki ngā anthracyclines me ngā taxans) i mua. Kua kawea mai e ia he tauira maimoatanga hou ki te mara o te chemotherapy mate pukupuku ū i Haina, ā, ka kawea mai hoki he maha atu ngā kōwhiringa maimoatanga mō ngā tūroro.
He aukati tubulin kore-taxane a Eribulin. Kāore i rite ki ngā aukati tubulin taxane me vinblastine, he tikanga mahi motuhake tā Eribulin, e whai hua tonu ai a Eribulin i roto i ngā tūroro whai muri i te ātete rongoā ki te yew; He pānga kore-cytotoxic anō hoki tā Eribulin, tae atu ki te whakahou i ngā oko toto, te whakanui ake i te rere o ētahi atu rongoā i roto i te taiao moroiti pukupuku, te whakakotahi i ētahi atu rongoā, me te huri i ngā pūtau pukupuku. Ko te whakawhiti epidermal-mesenchymal me ētahi atu.
Mai i te hanganga katoa o te halichondrin B, te whakamahinga o ngā matū parahi hou hei takawaenga, ki te whakarerekētanga hanganga o te Eribulin, ki te hanga ahumahi o te Eribulin, kua neke atu i te 20 tau te roa o te tūhuratanga a ngā kaipūtaiao o te ao mātauranga me ngā kamupene rongoā. Kua riro ngā hua taiao i ahu mai i te moana hei rongoā hei rongoā mō te mate pukupuku. Ko te rangahau me te whanaketanga o te Eribulin nā te mea he mea nui te matū parahi hou hei takawaenga matua o tana API. He mahi nui tā te matū parahi hou hei takawaenga rongoā me te matū hei horoi i ngā taputapu kounga teitei.
Kei roto i te hanganga ngota ngota o Eribulin e 19 ngā pokapū chiral, ā, ko ngā taahiraa hanga he 62 ngā taahiraa. Tae noa ki tēnei wā, e kiia tonutia ana a Eribulin e te umanga ko te rongoā kore-peptide tino uaua i hangaia e te hanga matū parakore, ā, ka taea te kī ko Maunga Everest i roto i te umanga hanga matū.
Ko te angitu o te rārangi o Eribulin e whakaata ana i ngā taumata hou ka taea e ngā kamupene rongoā te whakatutuki i roto i te hanganga matū me te whakaputa ahumahi. Ka kawea mai hoki e ia he maha atu ngā whakaaro me ngā kōwhiringa mō te tātaritanga me te maimoatanga ki ngā tākuta Hainamana. Ko te tumanako ka taea e te rongoā chemotherapy hou a Eribulin te kawe mai i te tumanako hou ki ngā tūroro mate pukupuku ū i roto i ngā mahi haumanu a meake nei.
Wā tuku: Hanuere-01-2021