Mosapride CAS:112885-41-3

Ko te Mosapride, he kaiwhakaoho whiriwhiri o te kaiwhakawhiwhi serotonin 5-HT4, he whiringa rongoā nui mō ngā mate puku e tohuhia ana e te ngoikore o te nekeneke me te dyspepsia mahi. Ko tana mahi matua ko te whakarei ake i te whakawhiti me te taunga o te puku, te aro ki ngā tohu pēnei i te mate puku roa, te dyspepsia kore-whewhe, me te mate reflux gastroesophageal (GERD). Hei tāpiri, e whakaatu ana te mosapride i te whai huatanga ki te whakahaere i te ileus postoperative me te gastroparesis mate huka, e whai wāhi ana ki te whakahoki mai i te waatea puku noa me te whakaiti i te mamae e pā ana. I roto i te mahi haumanu, ka tohua te mosapride ki ngā tūroro e pāngia ana e ngā tohu o ngā āhuatanga e pā ana ki te dysmotility, tae atu ki te pupuhi, te makona wawe, me te whakapairuaki anō. Ko tana tikanga mahi ko te whakatikatika i te tukunga acetylcholine i roto i te pūnaha io enteric, e arahi ana ki te whakanui ake i te peristalsis me te whakapai ake i te noho puku. Nā tēnei mahi rongoā ka tino whai hua te mosapride mō ngā tāngata e pāngia ana e te dyspepsia mahi, he mate noa e tohuhia ana e te mamae o te puku o runga me te mahi sensorimotor puku e raruraru ana. Hei tāpiritanga, he mahi nui tā te mosapride i roto i te whakahaere i te reflux gastroesophageal, e whai wāhi ana ōna pānga prokinetic ki te whakaiti i te pānga o te waikawa esophageal me te whakapai ake i ngā tohu e pā ana. Mā te whakatairanga i te whakawātea puku whai hua, ka āwhina i te whakaiti i te ruaki o ngā ihirangi o te puku ki roto i te esophagus, ā, ka whakapai ake i te kounga whānui o te oranga mō ngā tūroro e pāngia ana e tēnei mate. I te nuinga, ko ngā whakamahinga haumanu kanorau o te mosapride e whakaatu ana i tōna hiranga hei rongoā whai hua mō ngā mate nekenekehanga o te puku. Mā roto i tana whakatikatika i ngā ara serotonergic me te whakahaere i te taunga o te puku, ka tukuna e te mosapride he whakaora tohu whai hua me ngā putanga mahi pai ake mō ngā tāngata e raru ana ki te whānuitanga o ngā raruraru nakunaku.