Mecillinam CAS:32887-01-7

He mea noa te whakamahi i te Mecillinam i roto i ngā mahi haumanu hei rongoā i ngā mate mimi kore-raruraru (UTI) i puta mai i ngā huakita Gram-negative ngoikore, inā koa ko te Escherichia coli. Mā tōna whānuitanga whaiti o te mahi ka taea te rongoā hāngai ki ngā uropathogens noa, me te whakaiti i te whakararuraru i ngā flora noa. He mea pai te Mecillinam mō ngā UTI nā tōna whai huatanga, tōna haumaru, me te iti o te kaha ki te whakaoho i te ātete. Haunga ngā UTI, ka whakamahia te mecillinam mō te whakahaere i ētahi atu mate ā-rohe, pērā i te prostatitis me ngā mate manawa o raro, kei reira ngā huakita Gram-negative ngoikore e pāngia ana. Nā tōna kaha whiriwhiri ki ngā Enterobacteriaceae he mea nui hei rongoā i ēnei mate motuhake me te karo i te whakamahinga paturopi whānui kore e hiahiatia. Nā te hanganga ā-waha me ngā āhuatanga pharmacokinetic pai o te Mecillinam ka watea mō te rongoā ā-waho o ngā mate ngawari ki te ngoikore, ka taea e ngā tūroro te whakaoti i tā rātou akoranga rongoā. Ko tōna whai huatanga kua whakapumautia ki te arotahi ki ngā pathogens Gram-negative e whakaatu ana i tōna hiranga ki te whakahaere i ngā mate huakita ā-rohe. Hei tāpiri atu ki tēnā, ka whakamahia te mecillinam i roto i ētahi tikanga ārai mate hei ārai i ngā UTI e hoki mai ana, hei ārai rānei i te wā e pokanga ana ngā huakita Gram-negative ki te mate. Nā tōna kaha ki te whakatutuki i ngā kukū tiketike i roto i ngā kiko mimi me te whawhai pai ki ngā uropathogens, he mea nui tēnei hei ārai mate i roto i ngā āhuatanga haumanu motuhake. I te nuinga o te wā, he kōwhiringa paturopi nui te mecillinam i roto i te rongoā i ngā mate ā-rohe i puta mai i ngā huakita Gram-negative ngoikore, e tuku ana i tētahi huarahi rongoā whai hua me te whai kiko ki ngā tākuta me te iti o te mōrearea o te whanaketanga ātete. Nā tōna tūranga hei kaihoko whāiti-whāiti, he mea nui tēnei hei taputapu i roto i ngā mahi tiaki paturopi, e whakatairanga ana i te whakamahinga tika o ngā paturopi me te whakaiti i te putanga mai o ngā rauropi ātete-maha-rongoā.