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2′-O-Methyluridine CAS:2140-76-3 Utu Kaihanga
Ko te 2′-O-Methyluridine he nucleoside kua whakarerekētia kei roto he rōpū methyl i te tūranga 2′ o te mowhiti ribose. He poraka hanga nui tēnei i roto i te hanganga o ngā ngota RNA kua whakarerekētia, ā, kua rangahauhia mō ōna āhuatanga koiora me te rongoā pea. Ko ētahi o ana tono kua pūrongohia ko tōna whakamahinga i roto i te rangahau RNA, hei wāhanga i roto i te hanga RNA kua whakarerekētia mō ngā tono ira whakaora me te mahi, me te mea he taputapu i roto i te ako i te hanganga me te mahi RNA.
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4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one CAS:951-77-9
Ko te 2′-Deoxycytidine he nucleoside e titoa ana i te nucleobase cytosine e hono ana ki te huka deoxyribose. He wāhanga matua o te DNA, ā, he mahi nui tana i roto i te rokiroki me te tuku mōhiohio ira i roto i ngā rauropi ora.
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Cytidine-5′-monophosphate (CMP), waikawa kore utu CAS:63-37-6
Ko te Cytidine 5'-monophosphate (CMP) he nucleotide e mahi ana hei poraka hanga mō te hanga me te whakarerekētanga RNA. He wāhanga nui tēnei i roto i te hanganga o ngā ngota RNA, ā, e whai wāhi ana ki ngā tukanga pēnei i te taupoki mRNA me te pākia o te nucleotide. Ka whakamahia hoki te CMP i roto i te rangahau matū koiora me te koiora ngota mō ngā tono pēnei i te tuhi in vitro me te tapanga waikawa nucleic. Ko tōna tūranga i roto i te pākia o te RNA me tōna whakamahinga i roto i ngā tikanga whakamātautau maha e waiho ana hei taputapu nui hei mārama ki te hanganga me te mahi a ngā ngota RNA.
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IBMX, 3-isobutyl-1-methylxanthine CAS:28822-58-4
Ko te 3-isobutyl-1-methylxanthine, e mōhiotia ana ko IBMX, he matū methylxanthine e whakamahia whānuitia ana i roto i ngā rangahau pūtaiao hei aukati kore-motuhake i ngā phosphodiesterases nucleotide cyclic. E mōhiotia ana ka whakanui ake i ngā taumata intracellular o te cyclic AMP (cAMP) me te cyclic GMP (cGMP) mā te aukati i tō rātou pakaru, ka taea ai te whakarerekē i ngā ara tohu pūtau.
Haunga āna mahi rangahau, kua whakamahia a IBMX i roto i ētahi wāhi hauora mō ōna pānga whakawhanui i te manawa me te whakawhanui i te toto. Heoi, he iti noa iho tōna whakamahinga i roto i te rongoā tangata.
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4-Nitrophenyl phosphate disodium tote hexahydrate CAS: 4264-83-9
Ko te 4-Nitrophenyl phosphate disodium salt hexahydrate he matū e whakamahia whānuitia ana i roto i ngā rangahau matū koiora me ngā rangahau rongoā. He momo tote o te 4-nitrophenyl phosphate, kei roto ko ngā katote konutai e rua me ngā ngota wai e ono. He mea whakamahi noa tēnei matū hei matū mō ngā whakamātautau phosphatase me te ako i ngā mahi a te whākōkī.
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5′-Deoxy-5-fluorocytidine CAS:66335-38-4
Ko te 5′-Deoxy-5-fluorocytidine he momo nucleoside hangai e rangahauhia ana mō tōna kaha ārai huaketo pea, inā koa ki ngā huaketo RNA pēnei i te huaketo hepatitis C (HCV) me ngā flavivirus. Ka mahi mā te whakararuraru i te tāruarua o ngā rauemi ira huaketo, ā, i te mutunga ka aukati i te kaha o te huaketo ki te whakanui me te horapa i roto i te tinana.
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Cytidine-5′-triphosphate (CTP), tote disodium CAS:652154-13-7
Ko te Cytidine-5′-triphosphate (CTP), he tote disodium, he nucleoside triphosphate e mahi ana hei poraka hanga mō te hanga RNA. He mahi nui tāna i roto i te pākia o te pūtau, ā, he mea nui hoki mō te whakawhiti i ngā mōhiohio ira mai i te DNA ki te RNA i te wā o te tuhi. He whānuitia te whakamahinga o te CTP i roto i te rangahau koiora ngota, inā koa i roto i ngā rangahau e pā ana ki te hanga RNA, te pokanoa RNA, me ētahi atu tukanga e pā ana ki te RNA. Hei tāpiri, ka whakamahia i roto i ngā tauhohenga whākōkī, ngā rangahau pākia o te nucleotide, me te mea hei tūāpapa mō ngā whakamātautau matū koiora. I roto i te umanga rongoā, tera pea he tono pea a CTP i roto i te whakawhanaketanga o ngā rongoā ārai huaketo me te rongoā ārai matepukupuku.
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ITP, inosine 5′-triphosphate trisodium tote CAS:35908-31-7
Ko te tote Inosine-5′-triphosphate trisodium, e whakarapopototia ana ko ITP-Na3, he momo triphosphate o te inosine, he nucleoside e whai wāhi nui ana ki ngā tukanga koiora. He momo tote tēnei matū, e wairewa ana i te wai, ā, he pai mō te whakamahi i roto i ngā whakamātautau matū koiora me te whākōkī, tae atu ki te rangahau koiora ngota. Ka whakamahia te tote Inosine-5′-triphosphate trisodium mō te ako i ngā tauhohenga whākōkī, te whakawhitiwhiti nucleotide, me te mea he tūāpapa mō ētahi whākōkī. Ka horapa atu hoki ōna whakamahinga ki ngā rangahau anarau nucleotide me te mea he wāhanga i roto i te whakarite i ngā ranunga nucleotide e whakamahia ana i roto i ngā tikanga koiora ngota.
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5-Bromouracil CAS:51-20-7 Utu Kaihanga
Ko te 5-Bromouracil he rite hangai ki te uracil, he wāhanga o te RNA. Ka taea te whakauru i te 5-Bromouracil ki roto i ngā waikawa karihi, ā, ka taea te whakaputa i ngā whakarerekētanga mā te kore e honoa ki te guanine i te wā e tāruarua ana te DNA. Ka whakamahia hei matū whakarerekētanga ira i roto i ngā rangahau ira hei ako i ngā tere me ngā tikanga whakarerekētanga.
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5-Fluoro-2′-deoxyuridine CAS:50-91-9
Ko te 5-Fluoro-2′-deoxyuridine he momo nucleoside hangai e aukati ana i te hanganga DNA. Kua rangahauhia mō ōna āhuatanga ārai huaketo me te ārai pukupuku. Hei tāpiri, e whakamahia ana hei taputapu rangahau i roto i te koiora ngota me te matū koiora.
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Tote disodium Cytidine-5′-triphosphate CAS:36051-68-0
Ko te tote disodium Cytidine-5′-triphosphate (CTP-Na2) he nucleoside triphosphate e mahi ana hei poraka hanga i roto i te hanganga o te RNA. He mahi nui tāna i roto i te pākia o te pūtau, e mahi ana hei tūāpapa mō ngā RNA polymerases i roto i te whakawhitiwhiti kōrero, hei puna pūngao hoki mō ngā tauhohenga whākōkī. He maha ngā wā ka whakamahia te CTP-Na2 i roto i ngā rangahau koiora matū me te koiora ngota hei wāhanga i roto i ngā tauhohenga e uru ana ki te hanganga, te whakarerekētanga, me te whakahaere i te RNA. Ko tōna āhua tote disodium ka whakanui ake i tōna wairewatanga i roto i ngā otinga wai, ka māmā ake ai mō te whakamahi taiwhanga.
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Waikawa ribonucleic mai i te rewena a Baker CAS: 63231-63-0
Ko te waikawa ribonucleic (RNA) mai i te rewena a Baker, e mōhiotia ana ko Saccharomyces cerevisiae, e pā ana ki ngā ngota RNA kei roto i tēnei harore pūtau-kotahi noa. He maha ngā mahi nui e mahia ana e ia i roto i te pūtau, tae atu ki te hanga pūmua, te mahi whākōkī, me te whakahaere ira. He mea nui te RNA mai i te rewena a Baker ki ngā kaipūtaiao me ngā kairangahau e ako ana i te koiora ngota, te ira, me ngā tukanga pūtau. E whakamahia ana i roto i te whānuitanga o ngā whakamātautau me ngā rangahau hei whiwhi māramatanga ki te whakaaturanga ira, te tukatuka RNA, me ngā tikanga ngota e whai ana i ngā mahi pūtau.
