Candesartan CAS:139481-59-7 Kaihanga Kaihanga

Ko te Candesartan he kaitukino AT1 (angiotensin II receptor 1) whiriwhiri.Ko te antagonism o nga kaiwhakawhiwhi angiotensin te aukati i te vasoconstriction me te hanga o te aldosterone, e arahi ana ki te heke o te wai me te konutai i roto i te plasma toto.Ka whakaatu i nga paanga antihypertensive i roto i nga tauira kararehe.Ka whakamahia hei rongoa mo te ngoikore o te ngakau, hei antihypertensive.Karekau a Candesartan e pa ana ki te oranga o te pūtau, ki te whakanui ranei engari ka whakanui ake i te whakapuakitanga o te VEGF me te interleukin-8 i roto i te tikanga whakatipu o nga pūtau KU-19-19.Ka taea e Candesartan (0.1 nM) te whakaheke i te whakautu kirimana ki te angiostensin II tata ki te 50%.