Acetylthiocholine iodide CAS:1866-15-5

Ko te acetylthiocholine iodide te mea matua e whakamahia ana hei ine i te mahi a te whākōkī acetylcholinesterase (AChE). Ko te AChE te kawenga mō te wawahi i te neurotransmitter acetylcholine i roto i te pūnaha io. Mā te tāpiri o te acetylthiocholine iodide ki tētahi ranunga tauhohenga kei roto ko te AChE ka hua ake te thiocholine me te acetate.

Ka taea te kite i te tauhohenga mā te tāpiri i tētahi tohu tae-ira, tohu fluorometric rānei e tauhohe motuhake ana ki te thiocholine. He rite tonu te tere o te whakaputanga tae, te fluorescence rānei ki te mahi a te AChE i roto i te tauira. Nā tēnei ka waiho te acetylthiocholine iodide hei taputapu whai hua mō te ine i te mahi AChE i roto i ngā tauira koiora, tae atu ki ngā kiko, ngā ahurea pūtau, me te toto.

Ko te ine i te ngohe AChE mā te whakamahi i te acetylthiocholine iodide e whakamahia whānuitia ana i roto i ngā rangahau e pā ana ki ngā pūnaha cholinergic, ngā mate neurodegenerative, me te pānga ki ētahi matū, ki ētahi rongoā rānei ka pā ki te ngohe AChE. Ka taea hoki te whakamahi hei taputapu tirotiro mō te kimi i ngā aukati AChE, he mea nui ki te whakawhanake i ngā rongoā mō ngā mate pēnei i te mate a Alzheimer me te mate a Parkinson.

Haunga te whakamahinga i roto i ngā whakamātautau whākōkī, ka taea hoki te whakamahi i te acetylthiocholine iodide hei tūāpapa mō ngā pūoko koiora e hangai ana ki te AChE. Kua hangaia ēnei pūoko koiora hei kite me te ine i te aroaro o ētahi matū ka taea te aukati i te mahi AChE, pērā i ngā patupatu organophosphate me ngā kaihoko io.