Acetylcholinesterase CAS:9000-81-1

Ko te pānga anticholinesterase e pā ana ki te kaha o ētahi rongoā, matū rānei ki te aukati i te mahi a te whākōkī acetylcholinesterase. Ko te acetylcholinesterase te kawenga mō te wawahi i te neurotransmitter acetylcholine i roto i te tinana. Mā te aukati i tēnei whākōkī, ka whakanuia e ngā anticholinesterase ngā taumata o te acetylcholine, ka piki ake te mahi cholinergic.

Ko te whakamahinga matua o ngā anticholinesterases ko te rongoā i ngā āhuatanga e tohuhia ana e te ngoikore o te mahi cholinergic. Kei roto i ēnei ko ngā mate pūnaha io pērā i te mate a Alzheimer me te myasthenia gravis. I roto i te mate a Alzheimer, ka whakamahia ngā anticholinesterases pērā i te donepezil, rivastigmine, me te galantamine hei aukati i te pakaru o te acetylcholine me te whakarei ake i te tukunga o te neurocholinergic. Ka taea e tēnei te āwhina i te whakapai ake i te mahi hinengaro, ā, tera pea ka whakaroa i te haere whakamua o te mate.

I roto i te myasthenia gravis, ka whakamahia ngā anticholinesterases pēnei i te neostigmine me te pyridostigmine hei whakarei ake i te tukunga o ngā uaua io. Ka aukati ēnei rongoā i te acetylcholinesterase, ka whakanui ake hoki i ngā taumata o te acetylcholine i te hononga uaua io, ka whakapai ake i te kaha o te uaua me te whakaiti i te ngoikore o te uaua.

He whakamahinga tātaritanga me te rongoā anō hoki ngā anticholinesterases i roto i ngā take o te paihana anticholinergic. Ka taea e ngā matū anticholinergic, pērā i ētahi patu pepeke, ngā kaihoko io rānei, te whakararu i te aukati cholinergic nui rawa atu, ka arahi ki ngā tohu pēnei i te pōhēhē, te tere o te ngakau, te waha maroke, me te tirohanga pōuri. I roto i ēnei take, ka taea te whakamahi i ngā anticholinesterases pēnei i te pralidoxime hei whakakore i ngā pānga mā te whakanui ake i ngā taumata acetylcholine me te whakataetae ki ngā matū paitini.