Abiraterone CAS:154229-19-3

Ko te Abiraterone te mea nui e whakamahia ana i roto i te oncology hei whakahaere i te mate pukupuku repeure ātete-whakarewa metastatic (mCRPC). Hei aukati kaha i te biosynthesis androgen, ka aro atu ki te whākōkī CYP17A1, he mea nui ki te hanga testosterone me ētahi atu androgens. Mā te aukati i tēnei whākōkī, ka pehia e te abiraterone te hanga androgen i roto i ngā testes me roto i te pukupuku tonu, ā, ka whakaitihia ngā taumata o ngā androgens e whakatipu ana i te tipu o te mate pukupuku repeure. I roto i te haumanu, ka tukuna te abiraterone me te prednisone, te prednisolone rānei hei whakaiti i ngā pānga taha pea. Kua whakaatuhia e tēnei tikanga maimoatanga he whai huatanga nui ki te whakapai ake i ngā reiti oranga whānui me te whakaroa i te whanaketanga o te mate i roto i ngā tūroro he mate pukupuku repeure matatau kua whiwhi i te rongoā tango androgen (ADT) i mua. Hei tāpiri, ka horapa atu te pānga rongoā o te abiraterone ki tua atu i te mCRPC. Kei te tūhuratia tonutia e te rangahau tōna pūmanawa i ngā wāhanga tōmua o te mate pukupuku repeure me te whakakotahitanga me ētahi atu maimoatanga pēnei i te chemotherapy me ngā maimoatanga arotahi hou. Kei te tirotirohia tonutia tōna tikanga mahi me ngā painga haumanu puta noa i ngā whakamātautau haumanu hei whakapai ake i ngā putanga maimoatanga me te tiaki tūroro. Hei whakarāpopototanga, ko te abiraterone he tohu nui i roto i te rongoā mate pukupuku, inā koa i roto i te whakahaere mate pukupuku repeure. Ko tōna kaha ki te whakararuraru i te hanga androgen ka tuku i tētahi huarahi whai take ki te rongoā i ngā pukupuku e tairongo ana ki ngā homoni, ka roa ake te ora o ngā tūroro me te kounga o te oranga kua whakapaitia. Ko ngā whanaketanga tonu me ngā rangahau haumanu e whakaatu ana i tōna tūranga nui i roto i te whakawhanake i ngā rautaki maimoatanga mate pukupuku, e whakaari ana i ngā huarahi hou mō te tiaki mate pukupuku whaiaro.