1-METEHI-3-(TRIFLUOROMETEHI)-1H-PIRAZOLE-4-WAIKAWA KAROPOKIHI CAS:113100-53-1

Ka hangaia te waikawa 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic mā roto i ngā tikanga matū waro, e uru ana ki ngā tauhohenga e whakauru ana i ngā ngota fluorine me te rōpū methyl ki te pūtake pyrazole. He āhuatanga hanganga motuhake tō te ngota hua e whai kiko ana mō āna tono e hiahiatia ana i roto i ngā pūtaiao rongoā me te matū. Ngā Tono i roto i ngā Rongoā He pūhui tēnei e whakaatu ana i te kaha rongoā whai hua e pā ana ki ōna kaupapa hanganga. He rongonui ngā momo mahi rongoā a ngā pyrazole derivatives, mai i ngā āhuatanga antimicrobial ki te antitumor. Mā te whakaurunga o te rōpū trifluoromethyl ka taea te whakarerekē nui i te mahi koiora me te pumau o te pākia, ka taea te whakarei ake i te whai huatanga o te rongoā me ngā kōtaha haumaru. Ngā Mahi me ngā Tikanga Koiora E whakaatu ana ngā rangahau he maha ngā wā ka whakaatuhia e ngā pūhui kua whakakapia ki te trifluoromethyl te whakarei ake i te lipophilicity me te ātete pākia, ka pā ki ō rātou āhuatanga mimiti, tohatoha, pākia, me te whakaputanga (ADME). Ka taea e ēnei whakarerekētanga te arahi ki te whakapai ake i te bioavailability me ngā pānga rongoā roa, ka waiho hei kaitono pai mō te whanaketanga rongoā. Ngā Huarahi Hanga me te Whakawhanaketanga Ko te hanganga o te waikawa 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic he tukanga maha-taahiraa e tīmata ana mai i ngā rauemi tīmatanga e wātea ana i te hokohoko. Ko te arotautanga o ngā huarahi hanga he whakarei ake i te hua, te parakore, me te tauine, he mea nui mō ngā tono ahumahi me te whakaputanga tauine nui i roto i ngā tautuhinga rongoā. Rangahau o Nāianei me ngā Aronga ā-Mārama Kei te arotahi tonu ngā rangahau ki te whakamārama i te whānuitanga katoa o ngā mahi koiora e pā ana ki te waikawa 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic. Kei roto i tēnei ko te aromatawai i tōna whai huatanga ki ngā whāinga mate motuhake me te arotau i ngā whakatakotoranga mō ngā whakamātautau haumanu. Tērā pea ka tūhuratia e ngā rangahau ā-mōrama tōna pūmanawa hei hanganga turanga mō te hoahoa i ngā kaitono rongoā hou me ngā kōtaha rongoā kua whakaritea. Hei whakarāpopototanga, ko te waikawa 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic he ahunga whakamua nui i roto i te matū rongoā. Ko ōna āhuatanga hanganga motuhake me ngā mahi rongoā pea e whakaatu ana i tōna hiranga hei kaupapa rangahau pūtaiao me te auahatanga tonu i roto i te whanaketanga rongoā.